Detalhe da pesquisa
1.
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol
; : 1-16, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346140
2.
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Biochemistry
; 58(35): 3700-3710, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403283
3.
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
Biochem J
; 471(2): 131-53, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26431849
4.
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.
Chin J Cancer
; 33(2): 80-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845143
5.
Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery.
Mol Diagn Ther
; 28(2): 141-151, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38302842
6.
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.
Mol Cancer
; 12: 58, 2013 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23758947
7.
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506.
ACS Med Chem Lett
; 14(11): 1517-1523, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974941
8.
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours.
Cancer Gene Ther
; 29(2): 178-188, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558701
9.
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.
Pharmaceuticals (Basel)
; 15(2)2022 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35215297
10.
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit.
Cancer Gene Ther
; 29(7): 1021-1032, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34837065
11.
Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy.
Cells
; 10(5)2021 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33923305
12.
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.
Pharmaceuticals (Basel)
; 14(12)2021 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959631
13.
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.
Mol Cancer Ther
; 20(12): 2372-2383, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625504
14.
Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide.
Cancers (Basel)
; 12(6)2020 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32549357
15.
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
Cell Chem Biol
; 24(3): 391-403, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262557
16.
Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress.
Cancers (Basel)
; 8(7)2016 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27367731
17.
Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy.
Biochem Pharmacol
; 116: 176-87, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27453434
18.
Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.
Biochem Pharmacol
; 85(8): 1091-103, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23399641
19.
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.
Mol Cancer Ther
; 11(3): 740-51, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147748